There is a bug in Figures 4 and 6, S5 and S7. The colors of two labels (Limbic A & Limbic B) are swapped in the legends of the cortical atlas (see Fig. 4). Limbic A should refer to regions of the brain in the temporal lobes shown in the lighter color, while Limbic B should refer to regions in the orbitofrontal cortex shown in the darker color. The authors have provided corrected versions here.

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Fig. 6. RSFC correlates negatively with the time of day between participants, with one size exceeding the strength of the correlation between fluid intelligence and RSFC.

The results shown relate to session 1 (see S5 Fig. For session 2). (A) Correlation between time of day and RSFC between participants. (B) Correlation between Fluid Intelligence and RSFC between participants (with reversed color scale to facilitate visual comparison with time of day effects). Colors in the lower triangle of the correlation matrix indicate Pearson correlation coefficients. Colors in the upper triangle denote r-values ​​from the lower triangle, averaged within network pairs. Colors on marker axes indicate the correspondence of 419 regions to 17 large cortical networks and to SC. The association between time of day and RSFC was significant in both sessions, as assessed by network-based statistics (FDR-corrected at q <0.05), while the association between fluid intelligence and RSFC association was only significant in session 1 (FDR-corrected at q <) 0.05). For more information on network-based statistics, see Materials and Methods [51]. Fluid Intelligence was chosen because it is a widely used measure among resting fMRI studies of brain-behavioral associations [50] and is one of the behavioral measures best predicted by dormant fMRI [37,38,52]. Con, control network; DAN, dorsal attention network; DMN, standard mode network; FDR, false detection rate; fMRI, functional MRI; Lim, limbic network; RSFC, functional connectivity at rest; Sal, Salience Network; SC, subcortical network; SM, somatomotor network; TP, temporal parietal network; Vis, visual network.

https://doi.org/10.1371/journal.pbio.3001258.g002

Additional Information

S5 Fig. The RSFC region correlates negatively with the time of day between the participants in session 2 (n = 865) with a size that exceeds the strength of the correlation between fluid intelligence and RSFC.

(A) Correlation between time of day and RSFC between participants. (B) Correlation between Fluid Intelligence and RSFC between participants. Colors in the lower triangle of the correlation matrix denote z-transformed Pearson correlation coefficients. Colors in the upper triangle denote z-transformed r-values ​​from the lower triangle, averaged within network pairs. Colors on marker axes indicate the correspondence of 419 regions to 17 large cortical networks and to SC. The mean absolute z-values ​​calculated using the lower triangle were higher for the time of day (0.13) than for liquid intelligence (0.04). Time of day RSFC effects were significant, while RSFC fluid intelligence effects were not significant for session 2, as assessed by network-based statistics (FDR-corrected at q <0.05). Note that the Fluid Intelligence RSFC effects color gamut has been inverted to make it easier to compare visually with time of day effects. The results of session 1 can be found in Fig. 6 in the main text. FDR, false detection rate; RSFC, functional connectivity at rest; SC, subcortex.

https://doi.org/10.1371/journal.pbio.3001258.s001

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S7 Fig.Global signal regression reduces the size of negative correlations between RSFC and time of day, while in both sessions 1 positive correlations are introduced for several large circuits (N. = 937) and in session 2 (N. = 865).

(A) Correlation between time of day and RSFC between participants. (B) Correlation between Fluid Intelligence and RSFC between participants. The correlation levels are visibly stronger between time of day and RSFC than between Fluid Intelligence and RSFC. Colors in the lower triangle of the correlation matrix denote z-transformed Pearson correlation coefficients. Colors in the upper triangle denote z-values ​​from the lower triangle, averaged within network pairs. Colors on marker axes indicate the correspondence of 419 regions to 17 large cortical networks and to SC. Time of day RSFC effects were significant in both sessions as assessed by network-based statistics (FDR corrected at q <0.05), whereas Fluid Intelligence RSFC effects were only significant in session 1. FDR, false detection rate; RSFC, functional connectivity at rest; SC, subcortex.

https://doi.org/10.1371/journal.pbio.3001258.s002

(TIF)

reference

  1. 1.
    Orban C, Kong R, Li J, Chee MWL, Yeo BTT (2020) The time of day is associated with a paradoxical decrease in global signal fluctuation and functional connectivity. PLoS Biol 18 (2): e3000602. https://doi.org/10.1371/journal.pbio.3000602 pmid: 32069275

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