These results from Oncotarget suggest that PL reduces tumor growth and induces cell death by regulating the cell cycle

Oncotarget released “Piperlongumin promotes the death of retinoblastoma cancer cells“, Who reported that although retinoblastoma initiation is triggered by the inactivation of both alleles of the retinoblastoma tumor suppressor gene in the developing retina, tumor progression requires additional epigenetic changes since the retinoblastoma genomes are quite stable.

In this report, the authors analyzed the lethal effects of piperlongumin, a natural compound isolated from Piper longum L., on two human retinoblastoma cell lines, WERI-Rb and Y79. The effects of PL on cell proliferation, cell death and cell cycle were examined.

PL effectively inhibited cell growth, influenced the cell cycle by lowering cyclin and CDK1 levels and increasing CDKN1A, and triggered a caspase-3-independent cell death process in which the production of reactive oxygen species plays a major role.

Indeed, PL toxicity in retinoblastoma cell lines was inhibited by ROS scavenger N-acetyl-1-cysteine ​​treatment.

These Oncotarget results suggest that PL reduces tumor growth and induces cell death by regulating the cell cycle.

These Oncotarget results suggest that PL reduces tumor growth and induces cell death by regulating the cell cycle.

Dr. Nathalie Allaman-Pillet from the Institute for Ophthalmic Research in Switzerland said: “Retinoblastoma is a malignant tumor that originates from photoreceptor progenitor cells.

Although the survival rate of retinoblastoma patients in developed countries is extremely high, untreated advanced tumors limit eye maintenance and put patients at risk of metastasis and death.

A multi-stage model for the progression of the normal retina to retinoblastoma has been proposed, the first step being the inactivation of both alleles of the tumor suppressor gene RB1 in the developing retina.

PL has been described as an anti-cancer compound that modulates apoptosis, ROS production, cell proliferation, migration and invasion and exhibits selective cytotoxic effects on various cancer cell types including pancreatic, kidney, prostate and breast cancers.

In this report, they examined the death potential of PL on two human retinoblastoma cell lines, WERI-Rb and Y79.

The Allaman Pillet research team concluded in their Oncotarget research result: “Our study reports that PL induces retinoblastoma cell death through the accumulation of ROS, resulting in cellular oxidative stress. A possible role of FOXM1 in this cell death process must be demonstrated with inhibitors or after FOXM1 overexpression. These data provide in vitro evidence that PL could serve as a potential anticancer molecule in the treatment of retinoblastoma.

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DOI – https: //doi.Organization/10.18632 /onkoziel.27947

Full text – https: //www.onkoziel.com /Items/27947 /Text/

Correspondence – Nathalie Allaman-Pillet – [email protected]

keywords
Cancer,
Retinoblastoma,
Piperlongumin,
programmed cell death

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