Proteases induced by a neuroinflammatory response impede the recovery process from a brain injury; novel interactions between proteins (Hevin and Calcyon) help restore neurons in a mature brain

Patients with brain injuries (from stroke or trauma) rely primarily on rehabilitation therapy for recovery as no other effective treatments are known. The rate of recovery observed in adults from brain injury is significantly slower (or recovery is impossible) than in young children. Researchers agree that the number of excess neural stem cells that can restore brain function is less in a mature brain than in a young child’s brain.

A Korean research team reported a novel mechanism for describing the recovery process from brain injuries. The researchers reported that when performing the animal model experiment, the time to recovery from a brain injury could be controlled by regulating the proteins. The Korea Institute of Science and Technology (KIST) announced that a team led by Dr. Eun Mi Hwang from the Brain Science Institute, KIST, worked with another team led by Prof. Kyoungho Suk from the School of Medicine at Kyungpook National University and reported the existence of a new protein interaction (Hevin-Calcyon); This interaction plays a critical role in the recovery process from brain injury in adults. The researchers also showed that this interaction plays an important role in the early stages of recovery.

The researchers at KIST identified the calcyon protein as a novel interaction partner of hevin, a protein that is secreted by the glial cells in the brain. They also reported that the interaction between the proteins played a critical role in restoring neuronal cells in an injured adult brain. Since neurons are cells that directly affect brain activity, it is believed that brain diseases can be cured if they are cured and / or treated.

* Glial cells: cells that support the tissues of the central nervous system, supply nutrients to neurons in the brain and spinal cord, and create a chemical environment suitable for the activities of the neurons

The results of the experiments indicated that increasing the number of Hevin-Calcyon interactions in the brain could promote synaptic contacts and reorganization, which could aid in the early recovery of the compromised brain. The Hevin-Calcyon interaction and the expression of these proteins were confirmed by studying healthy brain tissue. It was also observed that the number of interactions was significantly reduced in patients with a state of traumatic brain injury.

Researchers at Kyungpook National University studied the recovery process from brain injury by studying the Hevin and Calyon interaction with an animal model of brain injury. They reported that the proteases induced by the neuroinflammatory response, formed in the early stages of brain injury, resulted in the fragmentation of Hevin. This also hindered the creation of the Hevin and Calyon interaction. The experiments were carried out using an animal model of the brain injury. It has been observed that recovery time could be reduced to approximately 2 to 3 weeks (from 4 weeks) when an anti-inflammatory drug was administered directly to the injured region of the brain. The recovery rate could be slowed down further by giving an additional inflammatory protein.

The joint research team reported that the lack of the Hevin-Calcyon interaction in the early stages (a critical phase in the recovery process from brain injury) of the recovery process could negatively impact the effective recovery process. The reported result is the result of five years of efforts by the team around Dr. Eun Mi Hwang from KIST (this team identified the novel interaction between proteins), the team around Dr. Hoon Ryu from KIST (this team studied human traumatic brain injury) and a team led by Prof. Kyoungho Suk from Kyungpook National University (this team studied the properties of inflammation in different animal models). Each team contributed to the results based on their area of ​​expertise.

Dr. Eun Mi Hwang from KIST said, “The Hevin-Calcyon interaction may help in the treatment of brain diseases as brain injuries and neurodegenerative diseases can lead to the formation of inflammatory responses.” She added, “The results can potentially help process development.” help treat refractory brain diseases caused by impaired synaptogenic activity. “

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This research was conducted as part of the Core Technology Development Project in Neuroscience, funded by the National Research Foundation of Korea and supported by the Ministry of Science and ICT (MSIT). The results were published in the current issue of “Cell death & differentiation “(IF: 10,717, Top 6.229% in JCR), an international scientific journal.

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