De novo genome assembly and analysis reveal biosynthetic and metabolic potentials of Pseudomonas fragi A13BB; – Did imports of sweetened beverages into Pacific Island countries increase between 2000 and 2015 ?; – A qualitative study of the experiences of NHS workers in the psychiatric field during the Covid-19 pandemic; – Cultures and Remedies: Neurodiversity and Brain Organoids; – The effects of vitamin and mineral supplementation in women with gestational diabetes mellitus

BMC genomic data: De novo genome assembly and analysis reveal biosynthetic and metabolic potentials of Pseudomonas fragi A13BB

Akansha Jain, Sampa Das, CC BY 4.0 via Wikimedia Commons

Pseudomonas fragi A13BB, obtained from soil samples from the rhizosphere as part of a study to identify new antibiotic-producing bacterial strains, was sequenced for antibiotic-producing gene clusters and presented as the first data note in. released BMC genomic data. Plant growth-promoting rhizobacteria (PGPR) are one of the constituents of the rhizosphere, where they promote plant growth by increasing the absorption of nutrients, inorganic elements or resistance to heavy metals, high salt concentrations, phytopathogens and more.

Two β-lactone secondary metabolite biosynthesis gene clusters (smBGC) known for their antibiotic, anti-obesity and anti-cancer properties were identified and showed low homology (20%) to known smBGCs. A siderophore (a small compound normally secreted to carry iron across cell membranes) smBGC has been identified, though P. fragi is considered a non-siderophore-producing member of the genus gen Pseudomonas.

BMC diet: Did imports of sweetened beverages into Pacific Island countries increase between 2000 and 2015?

דוד שי, CC BY-SA 3.0 via Wikimedia Commons

The aim of this study was to identify trends in the variety and amount of sweetened beverages (SB) imported into Pacific Island countries (and the impact of SB taxes on imports into Fiji and Tonga). Diet-related chronic diseases are one of the leading causes of death and illness in these countries.

The authors found that between these points in time there was an increase in self-service imports into the Pacific island states, which must be taken into account by both the exporting and importing countries in terms of health effects, as this is detrimental to nutrition and the Self-sufficiency affects. A diet high in processed foods is known to have an impact on health. There was a statistically significant increase in self-service imports to Tonga, but too little data for tax assessment.

BMC Psychiatry: A qualitative study of NHS workers’ experiences in the psychiatric field during the Covid-19 pandemic

Murat Karabulut via Wikimedia Commons

Thirty-five members of the secondary mental health services of the NHS (England) conducted an interview-based study and had difficulties that had a significant impact on their well-being during the pandemic.

The lockdown in England in response to the SARS-CoV-19 pandemic had an impact on all health care workers, but under-reported this on mental health workers. Respondents’ quality of life was affected by the challenge of providing care in cramped and potentially dangerous situations and losing patients to the disease. Taking on additional tasks to better care for their patients led to additional stress. Feelings of sadness, helplessness, isolation, distress, and burnout have been reported. The response to the pandemic meant that services had to adapt quickly to the severe incident mode, while at the same time the needs of service users increased. Some got morally injured after being exposed to this event.

This study has indicated areas where additional support could be sought. One implication is the loss of staff, but this was not specifically mentioned.

BMC medical ethics: Cultures and Remedies: Neurodiversity and Brain Organoids

Cells from donors with autism spectrum disorder (ASD) can now be grown into brain organoids, and the resulting research opens up our understanding of the etiology of ASD. Brain organoids enable research into genetic, developmental and other factors involved, which makes this unique compared to other forms of research. Researchers often incorporate the medical model of disability into ASA research.

The neurodiversity movement is unlikely to be inconsistent with the approaches and goals of cerebral research in ASD, as the developmental disability movement and paradigm understand autism as a form of human diversity and advocate a model based on social, attitudinal, and environmental barriers rather than deficits.

NIH image gallery from Bethesda, Maryland, USA via Wikimedia Commons

The authors make three recommendations that should minimize any conflict and achieve a more holistic, integrative approach to cerebral organoid research on ASA.

1 – Neurodiverse people should be involved as co-creators both in the scientific process and in research communication.

2 – Clinicians and neurodiverse communities should communicate openly and respectfully.

3 – A continuous redesign of illness, impairment, handicap, behavior and person should be achieved.

Researchers are advised to be careful not to combine illness with impairment or disability and to consider how best to communicate their ideas with respect and care.

Endocrine Disorders of the BMC: The effects of vitamin and mineral supplementation in women with gestational diabetes

Gestational diabetes mellitus (GDM) is defined as impaired glucose tolerance that begins or is recognized for the first time during pregnancy. It’s pretty widespread, with a figure of 15-20% reported worldwide. Hyperglycemia is associated with negative consequences for both mother and child.

Towle Neu, CC BY 2.5 via Wikimedia Commons

Vitamin and mineral supplements such as vitamin D, vitamin E, magnesium and selenium can regulate glucose metabolism and play a positive role in anti-inflammatory and antioxidant stress .; does it help in the GDM? The effects of vitamin and mineral supplementation on women with GDM are not well documented, but this meta-analysis hoped to correct this.

The authors’ findings are that vitamin and mineral supplementation; Magnesium, zinc, selenium, calcium, vitamins D and E (alone or in combination), significantly improved glycemic control, decreased inflammation and oxidative stress in women with GDM by lowering fasting serum plasma levels, insulin and other levels and increasing total antioxidant Capacity levels or


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