Leather production is the most important recycling technology for the biomass of natural skin. However, leather-based goods are traditionally made by chrome tanning, but the discharge of chrome-containing waste poses potential threats to the environment and public health. In comparison, the aldehyde / chrome-free tanning strategy for leather production is ecological. Therefore, in this study, a number of epoxy-terminated hyperbranched poly (amine ester) materials (abbreviated as EHBPs) were synthesized by epichlorohydrin-modified hydroxy-terminated hyperbranched poly (amine esters) (HHBPs). Comprehensive material characterization and tests of the novel EHBPs tanning agent showed that the hydrothermal stability of treated leather improved significantly at a shrinkage temperature (Ts) of over 75 ° C, good physical properties and a thickening ratio (> 50%). In addition, the EHBPs tanning approach ensured a high dispersity of the collagen fibers with significantly increased porosity (control 41%, EHBPs-tanned leather> 51%). The environmental impact assessment showed the preferred biodegradability of EHBPs (BOD5 / COD> 0.3). In summary, it can be said that the proposed EHBP-based tanning approach is very promising for realizing environmentally friendly leather production for the next generation of green chrome-free tanning.